We are doing weekly update posts on our research findings and just general information about the state of Aging research. See the latest articles below:
Collapsible
Introduction Aging is a complex biological process involving genetic and molecular changes that lead to progressive decline in function. Model organisms like the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae have been instrumental in uncovering conserved aging mechanisms. C. elegans is a multicellular eukaryote with a short lifespan …
Introduction Single-celled eukaryotes – including yeasts, protists, and unicellular algae – might seem immortal, dividing indefinitely under ideal conditions. Yet research reveals that even these microscopic organisms can age, exhibiting physiological changes and declining replicative capacity over time. This article explores how and why aging occurs in unicellular eukaryotes, from …
Introduction to Bacterial Aging Bacteria, long considered immortal due to their ability to divide indefinitely under favorable conditions, have recently been shown to exhibit aging, or senescence, characterized by a decline in reproductive ability and increased susceptibility to stress over time. This survey note explores the evolution of aging in …
State on February 2025 Aging, a universal and intricate biological process, has been the subject of extensive scientific inquiry, leading to a diverse array of theories aimed at elucidating why organisms age and eventually die. These theories, often debated and refined over decades, can be broadly categorized into programmed and …
The state on Feb 2025. Key Points
- C. elegans aging involves insulin/IGF-1, mTOR, sirtuin, and AMPK pathways, with epigenetic and stress responses also playing roles.
- We know these pathways extend lifespan, but exact mechanisms and tissue interactions are unclear.
- Surprisingly, C. elegans studies suggest potential human aging treatments, like …